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Comment & Response
March 20, 2024
VadimZakiev,MD1; AnnaGvozdeva,MD2; AntonSkotnikov,MD, PhD3
Author Affiliations Article Information
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1Russian Clinical and Research Center of Gerontology, Pirogov Russian National Research Medical University, Moscow, Russia
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2Chazov National Medical Research Center of Cardiology, Myasnikov Institute of Clinical Cardiology, Moscow, Russia
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3Department of Medical and Social Assessment, Emergency, and Ambulatory Practice, Sechenov First Moscow State Medical University, Moscow, Russia
JAMA. 2024;331(15):1332. doi:10.1001/jama.2024.0620
- Original Investigation Traditional Chinese Medicine Compound and Clinical Outcomes of Patients With Acute Myocardial Infarction
YuejinYang,MD, PhD; XiangdongLi,MD, PhD; GuihaoChen,MD, PhD; YingXian,MD, PhD; HaitaoZhang,MD, PhD; YuanWu,MD; YanminYang,MD; JianhuaWu,MD; ChuntongWang,MD; ShenghuHe,MD; ZhongWang,MD; YixinWang,MD; ZhifangWang,MD; HuiLiu,MD; XipingWang,MD; MinzhouZhang,MD; JunZhang,MD, PhD; JiaLi,MD; TaoAn,MD; HaoGuan,MD; LinLi,MD; MeixiaShang,MD; ChenYao,MD; YalingHan,MD, PhD; BoliZhang,MD; RunlinGao,MD; Eric D.Peterson,MD, MPH; CTS-AMI Investigators; YuejinYang; JianhuaWu; ChuntongWang; ShenghuHe; ZhongWang; YixinWang; YongquanJing; LinqiangLiu; XuxiaZhang; HanjunPei; YuzengXue; GuanzhongZheng; ChangyuWang; ZhongmingZhao; YanjieZheng; BaoliangDuan; GaoxingZhang; HuiLiu; ZhifangWang; ZeyuanFan; WenzhaiCao; HuanyiZhang; XiaoyongQi; XipingWang; GuoqingWu; FengGao; ZidongBie; LongYue; HengHong; JunQian; BingguangDai; WeiguangDou; LimingYue; ZhongqunZhan; ManLiu; XiaohongGao; YitianLian; YiZheng; JiangwuZhang; RonghaiMan; PengDong; LianlingWu; JunguoDeng; YongGuo; MinzhouZhang; JiaLi; ZheyingWang; PeishengDai; GulengSiri; QimingXu; XinyangLi; KeqingLi; ShengliHan; HuaixinWang; XiaLi; PingYang; HaowenZhang; YuesenLiu; BoXin; MenglangZhang; ZhiduoCao; MengZhang; GangMa; LeiWang; JunSong; WeiguoLi; HongchunLi; ZhengluShang; OuhuaFeng; HongjunZhang; HongtaoGao; RongqiBao; FengshunWang; LinqingShang; LeiQin; JianpingWang; GenshanMa; JiayuCui; ShixiWang; FangzhouCheng; ShujiangZhang; XianshiLiu; ChunxiCha; MinSun; WenbaoHan; HangLu; HaiyingWang; HongguangZhu; WeiWang; ZhiliWang; YufengGuo; HaishengZhang; ZhongShao; XirongCui; ChanglinLu; ZhanLv; JiyinZhang; GuangkaiCui; HongweiZhang; YingHan; WenliLiu; BingfengZhou; HuaGe; LiqunZhang; TaihongChen; BingyingNiu; BaoxiMu; JiaoZhang; HuaiminGuan; YuhuChun; HuaZhang; FangjiangLi; ShufangYin; XuWang; XiaoZou; JunshuaiSong; LangHong; MingqiZheng; BoJiang; ShuyingLiu; RuiZhu; WenboLiu; JieZhang; BinWu; ZongguiWu; QuanFang; ZuyiYuan; ChuanyuGao; HongJiang; XinliLi; PeiliBu; WeiGao; HongxuLiu; YingXian; RunlinGao; BoliZhang; YalingHan; JunboGe; EricPeterson; ShaoliangChen; JielinPu; QingshanZheng; CongxinHuang; WeifengShen; YuanWu; ChenYao; XiaoyanYan; MeixiaShang; XiaohanFan; HuaibingCheng; WenlanChang; HuiWang; ZhiLi; WenxuanZhai; ZhenghuiZhu; HuiLi; JianpengWang; JinTao; BoXu; MeiyingSun; FanWu; TongqiangZou; YueChang; PengYin; Junyan Shen; Yaxing Zhang; Yunfei Huang; GuihaoChen; XiangdongLi; YiXu; JingangYang; HaitaoZhang; ChenJin; MinWang
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GuihaoChen,MD, PhD; MeixiaShang,MD; YuejinYang,MD, PhD
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To the Editor A recent article1 reported a positive effect of a traditional Chinese drug (Tongxinluo) on outcomes of patients with acute myocardial infarction. Tongxinluo is a mixture of powders and extracts from multiple plant and insect products, so the concentration of active components may vary. Therefore, we have concerns about the stability of its effect. For example, the extract of plant Butea superba (Roxb) was more effective for erectile dysfunction than sildenafil in the first part of a study,2 but was not more effective in the second part of the study when another batch of B superba extract was used. The authors concluded that the first batch of B superba extract contained phosphodiesterase-5 inhibitor, while the second preparation did not. This study demonstrated the variable effects of plant extracts due to differences in their active components and their concentration in these products. We believe that special regulation for “natural” drugs must be implemented to resolve this issue.
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Zakiev V, Gvozdeva A, Skotnikov A. Traditional Chinese Medicine Compound and Clinical Outcomes in Acute Myocardial Infarction. JAMA. 2024;331(15):1332. doi:10.1001/jama.2024.0620
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